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KMID : 0361520110220010049
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Korean Journal of Psychopharmacology
2011 Volume.22 No. 1 p.49 ~ p.56
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The Influence of Apolipoprotein E ε4 and Lipid Profile on Cognitive Function in Community-Dwelling Elders with Mild Cognitive Impairment
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Kim Tae-Ho
Seo Jeong-Seok
Kim Tong-Wook
Moon Seok-Woo
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Abstract
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ObjectivezzThe aim of this study is to examine the relationship between lipid profiles including total cholesterol (TC), triglyseride (TG), high-density lipoprotein cholesterol (HDL-cholesterol), and low-density lipoprotein cholesterol (LDL-cholesterol) and cognitive function by the occurrence of the apolipoprotein E (APOE) ε4 in the community-dwelling elderly individuals with mild cognitive impairment (MCI). MethodszzThe total number of subjects was 203 (77 men and 126 women) who were diagnosed with MCI from a Korean pro-ject of “Early Detection of Dementia”. Aged 65-85 years were included in this analysis. The eight neuropsychological domain from the Korean version of Consortium to Establish a Registry of Alzheimer’s Disease neuropsychological test battery (CE-RAD-K, NP) were conducted to test subjects. The lipid profiles of all subjects were measured including TC, TG, HDL-cholesterol, and LDL-cholesterol levels and the correlation between the lipid levels and the neuropsychological test scores was analyzed by the occurrence of the APOE ε4. ResultszzThere was significant correlation between HDL-C and Word List Recall Test (WLRT) of the neuropsychological test score in CERAD-K (NP) in the presence of APOE ε4 (WLRT/HDL-C: r=0.163, p<0.05). ConclusionzzThe HDL-C level might be correlated with verbal episodic memory domain in CERAD-K (NP) test in the presence of APOE ε4 in community-dwelling elders diagnosed with MCI.
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KEYWORD
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Mild cognitive impairment · Apolipoprotein E · high-density lipoprotein cholesterol ·Korean version of Consortium to Establish a Registry of Alzheimer’s Disease · Cognitive function.
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